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Article

Alterations of the INK4a-ARF gene locus in pleomorphic adenoma of the parotid gland.

The Journal of pathology - 1 Nov 2002

Weber Anette, Langhanki Larissa, Schütz Alexander, Wittekind Christian, Bootz Friedrich, Tannapfel Andrea

Abstract excerpt

Pleomorphic adenomas of the parotid gland are benign tumours composed of epithelial and mesenchymal cells. The INK4a-ARF (CDKN2A) locus on chromosome 9p21 encodes two tumour suppressor proteins, p16(INK4a) and p14(ARF), which act as upstream regulators of the Rb-CDK4 and p53 pathways. To study the contribution of each pathway in pleomorphic adenomas, this study analysed alterations of p14(ARF), p16(INK4a), p53,...

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Identifiers

PMID: 12375265
DOI: 10.1002/path.1210

Genes

CDK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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