Effect of DNA repair gene polymorphisms on BPDE-DNA adducts in human lymphocytes.

doi:10.1002/ijc.10463

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Article

Effect of DNA repair gene polymorphisms on BPDE-DNA adducts in human lymphocytes.

International journal of cancer - 1 Jul 2002

Pastorelli Roberta, Cerri Annalisa, Mezzetti Maurizio, Consonni Erica, Airoldi Luisa

Abstract excerpt

To determine whether variations in DNA repair genes are related to host DNA damage, we investigated the association between polymorphism in the XPD gene (codon 199, 312, 751) and the XRCC1 gene (codon 194, 399) and the presence of benzo(a)pyrene diolepoxide adducts to lymphocyte DNA (BPDE-DNA) in a group of male patients with incident lung cancer, all current smokers. BPDE-DNA adducts were analyzed by...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
DNA Adducts
DNA Damage
DNA Helicases
DNA Repair
DNA-Binding Proteins
Gas Chromatography-Mass Spectrometry
Genotype
Humans
Lung Neoplasms
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Proteins

Smoking

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 12115580
DOI: 10.1002/ijc.10463

Genes

XRCC1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12115580-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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