Article
The Effect of Polymorphisms in DNA Repair Genes and Carcinogen Metabolizers on Leukocyte Telomere Length: A Cohort of Healthy Spanish Smokers.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Apr 2016
Verde Zoraida, Reinoso-Barbero Luis, Chicharro Luis, Resano Pilar, Sánchez-Hernández Ignacio, Rodríguez González-Moro Jose Miguel, Bandrés Fernando, Gómez-Gallego Félix, Santiago Catalina
Abstract excerpt
INTRODUCTION: Smoking implies exposure to carcinogenic agents that causes DNA damage, which could be suspected to enhance telomere attrition. To protect and deal with DNA damage, cells possess mechanisms that repair and neutralize harmful substances. Polymorphisms altering DNA repair capacity or carcinogen metabolism may lead to synergistic effects with tobacco carcinogen-induced shorter telomere length...
Topics
- Adult
- Aged
- Alleles
- Carcinogens
- Cohort Studies
- DNA Repair
- DNA-Binding Proteins
- Humans
- Leukocytes
- Middle Aged
- Polymorphism, Genetic
- Smoking
- Spain