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Article

ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review.

American journal of epidemiology - 1 Jan 2005

Benhamou Simone, Sarasin Alain

Abstract excerpt

The xeroderma pigmentosum group D (XPD) protein is a well-characterized DNA helicase necessary for the nucleotide excision repair of bulky DNA lesions, such as those induced by cigarette smoking. Polymorphisms in several exons of the XPD gene have been identified; two of them, Asp312Asn and Lys751Gln, are common and result in an amino acid change. Most of the reported data indicate higher levels of DNA adducts in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15615908
DOI: 10.1093/aje/kwi018

Genes

ERCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review.PMID 15615908Read ↗

DNA repair gene XPD polymorphism and lung cancer risk: a meta-analysis.Semantic proximity Read ↗

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Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility: a systemic review and meta-analysis.Semantic proximity Read ↗

ERCC2/XPD Lys751Gln and Asp312Asn gene polymorphism and lung cancer risk: a meta-analysis involving 22 case-control studies.Semantic proximity Read ↗

Sequence variations in the DNA repair gene XPD and risk of lung cancer in a Chinese population.Semantic proximity Read ↗

Association between the XPD/ERCC2 Lys751Gln polymorphism and risk of cancer: evidence from 224 case-control studies.Semantic proximity Read ↗

Polymorphisms in ERCC1 and ERCC2/XPD genes and carcinogen DNA adducts in human lung.Semantic proximity Read ↗

ERCC2/XPD gene polymorphisms and cancer risk.Semantic proximity Read ↗

Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population.Semantic proximity Read ↗

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Genetic polymorphisms of XPD and CDA and lung cancer riskSemantic proximity Read ↗

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