Article
Genetic polymorphisms in DNA repair genes and risk of lung cancer.
Carcinogenesis - 1 Apr 2001
Butkiewicz D, Rusin M, Enewold L, Shields P G, Chorazy M, Harris C C
Abstract excerpt
Polymorphisms in DNA repair genes may be associated with differences in the repair efficiency of DNA damage and may influence an individual's risk of lung cancer. The frequencies of several amino acid substitutions in XRCC1 (Arg194Trp, Arg280His and Arg399Gln), XRCC3 (Thr241Met), XPD (Ile199Met, His201Tyr, Asp312Asn and Lys751Gln) and XPF (Pro379Ser) genes were studied in 96 non-small-cell lung cancer (NSCLC)...
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