Article
Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK.
Environmental and molecular mutagenesis - 1 Jan 2004
Affatato Alessandra A, Wolfe Kevin J, Lopez Mirtha S, Hallberg Csilla, Ammenheuser Marinel M, Abdel-Rahman Sherif Z
Abstract excerpt
Polymorphisms in DNA-repair genes could contribute to the interindividual differences in cancer susceptibility in smokers. By reducing DNA-repair capacity, these polymorphisms may influence the net level of smoking-induced genetic damage significantly, a critical step in the cascade of events leading to cancer. In this biomonitoring study, we examined the relationship between polymorphisms in the DNA-repair gene...
Topics
- Adult
- Aged
- Alleles
- Case-Control Studies
- Chromosome Aberrations
- Cytogenetic Analysis
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- Environmental Monitoring
- Female
- Genotype
- Humans