Article
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.
Science (New York, N.Y.) - 12 Jul 2002
Cohen Paul, Miyazaki Makoto, Socci Nicholas D, Hagge-Greenberg Aaron, Liedtke Wolfgang, Soukas Alexander A, Sharma Ratnendra, Hudgins Lisa C, Ntambi James M, Friedman Jeffrey M
Abstract excerpt
Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. To examine the mechanism underlying leptin's metabolic actions, we used transcription profiling to identify leptin-regulated genes in ob/ob liver. Leptin was found to specifically repress RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the biosynthesis of monounsaturated...
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