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Article

Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice

5 Apr 2010

Abstract excerpt

The heart of leptin-deficient ob/ob mice is characterized by pathologic left ventricular hypertrophy along with elevated triglyceride (TG) content, increased stearoyl-CoA desaturase (SCD) activity, and increased myocyte apoptosis. In the present study, using an ob/ob;SCD1(-/-) mouse model, we tested the hypothesis that lack of SCD1 could improve steatosis and left ventricle (LV) function in leptin deficiency. We...

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PMID: 20363835
DOI: 10.1194/jlr.m003780

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