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Article

Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

1 Feb 2004

Abstract excerpt

Lipodystrophy is characterized by the complete or partial absence of adipose tissue, insulin resistance, hepatic steatosis, and leptin deficiency. Here, we show that low-dose central leptin corrects the insulin resistance and fatty liver of lipodystrophic aP2-nSREBP-1c mice, while the same dose given peripherally does not. Central leptin also repressed stearoyl-CoA desaturase-1 (SCD-1) RNA and enzymatic activity,...

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PMID: 14755338
DOI: 10.1172/jci19511

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