Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 Activation in adipocytes of obese mice.

The Journal of biological chemistry - 11 Jul 2003

Yahagi Naoya, Shimano Hitoshi, Matsuzaka Takashi, Najima Yuho, Sekiya Motohiro, Nakagawa Yoshimi, Ide Tomohiro, Tomita Sachiko, Okazaki Hiroaki, Tamura Yoshiaki, Iizuka Yoko, Ohashi Ken, Gotoda Takanari, Nagai Ryozo, Kimura Satoshi, Ishibashi Shun, Osuga Jun-Ichi, Yamada Nobuhiro

Abstract excerpt

The tumor suppressor p53 is a transcription factor that activates or represses its target genes after various genotoxic stresses. We have previously shown that sterol regulatory element-binding protein-1 (SREBP-1), a key transcriptional regulator of triglyceride synthesis, and the lipogenic enzymes under its control are markedly suppressed in adipocytes from genetically obese ob/ob mice. Here we demonstrate that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Blotting, Northern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCAAT-Enhancer-Binding Proteins

Share to Down-Regulation

Share to Immunoblotting

Share to Luciferases

Share to Mice, Obese

Share to Sterol Regulatory Element Binding Protein 1

Source

Identifiers

PMID: 12734185
DOI: 10.1074/jbc.M302364200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 Activation in adipocytes of obese mice.PMID 12734185Read ↗

The Intricate Role of p53 in Adipocyte Differentiation and FunctionSemantic proximity Read ↗

p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesitySemantic proximity Read ↗

Role of p53 in preadipocyte differentiationSemantic proximity Read ↗

Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic ApproachesSemantic proximity Read ↗

Control of metabolism by p53 – Cancer and beyondSemantic proximity Read ↗

p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitisSemantic proximity Read ↗

p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cellsSemantic proximity Read ↗

A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53.Semantic proximity Read ↗

Adipose tissue gene expression profiles in ob/ob mice treated with leptinSemantic proximity Read ↗

Protective effect of the Y220C mutant p53 against steatosis: good news?Semantic proximity Read ↗

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.Semantic proximity Read ↗

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.