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Article

Mouse Embryonic Fibroblasts Protect ob/ob Mice From Obesity and Metabolic Complications.

Endocrinology - 1 Sept 2018

Ferguson Daniel, Blenden Mitchell, Hutson Irina, Du Yingqiu, Harris Charles A

Abstract excerpt

The global obesity epidemic is fueling alarming rates of diabetes, associated with increased risk of cardiovascular disease and cancer. Leptin is a hormone secreted by adipose tissue that is a key regulator of body weight (BW) and energy expenditure. Leptin-deficient humans and mice are obese, diabetic, and infertile and have hepatic steatosis. Although leptin replacement therapy can alleviate the pathologies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30085057
DOI: 10.1210/en.2018-00561
PMCID: PMC6109302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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