Article
Phenotypic abnormalities in macrophages from leptin-deficient, obese mice.
The American journal of physiology - 1 Feb 1999
Lee F Y, Li Y, Yang E K, Yang S Q, Lin H Z, Trush M A, Dannenberg A J, Diehl A M
Abstract excerpt
Obesity is a complex syndrome that involves defective signaling by a number of different factors that regulate appetite and energy homeostasis. Treatment with exogenous leptin reverses hyperphagia and obesity in ob/ob mice, which have a mutation that causes leptin deficiency, proving the importan...
Topics
- Animals
- CCAAT-Enhancer-Binding Proteins
- Cyclooxygenase 2
- DNA-Binding Proteins
- Dinoprostone
- Homeostasis
- Hydrogen Peroxide
- Interleukin-6
- Ion Channels
- Isoenzymes
- Leptin
- Macrophages, Peritoneal
- Membrane Transport Proteins
- Mice
- Mitochondria
- Mitochondrial Proteins
- Nuclear Proteins
- Obesity