Article
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.
The Journal of biological chemistry - 31 May 2002
Yahagi Naoya, Shimano Hitoshi, Hasty Alyssa H, Matsuzaka Takashi, Ide Tomohiro, Yoshikawa Tomohiro, Amemiya-Kudo Michiyo, Tomita Sachiko, Okazaki Hiroaki, Tamura Yoshiaki, Iizuka Yoko, Ohashi Ken, Osuga Jun-Ichi, Harada Kenji, Gotoda Takanari, Nagai Ryozo, Ishibashi Shun, Yamada Nobuhiro
Abstract excerpt
Obesity is a common nutritional problem often associated with diabetes, insulin resistance, and fatty liver (excess fat deposition in liver). Leptin-deficient Lep(ob)/Lep(ob) mice develop obesity and those obesity-related syndromes. Increased lipogenesis in both liver and adipose tissue of these mice has been suggested. We have previously shown that the transcription factor sterol regulatory element-binding...
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