Article
Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk.
American journal of industrial medicine - 1 Jul 2002
Schabath Matthew B, Spitz Margaret R, Delclos George L, Gunn Gary B, Whitehead Lawrence W, Wu Xifeng
Abstract excerpt
BACKGROUND: As observed in tobacco-associated carcinogenesis, genetic factors such as the polymorphic metabolic/oxidative enzyme myeloperoxidase (MPO) could modulate individual susceptibility to asbestos-associated carcinogenesis. METHODS: RFLP-PCR analysis identified the MPO genotypes in 375 Caucasian lung cancer cases and 378 matched controls. An epidemiological interview elicited detailed information regarding...
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