Article
Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Feb 2007
Taioli Emanuela, Benhamou Simone, Bouchardy Christine, Cascorbi Ingolf, Cajas-Salazar Nohelia, Dally Heike, Fong Kwun M, Larsen Jill E, Le Marchand Loic, London Stephanie J, Risch Angela, Spitz Margaret R, Stucker Isabelle, Weinshenker Brian, Wu Xifeng, Yang Ping
Abstract excerpt
Myeloperoxidase is a phase I metabolic enzyme that converts the metabolites of benzo[a]pyrene from tobacco smoke into highly reactive epoxides. A polymorphism in the promoter region of myeloperoxidase (463G-->A) has been found to be inversely associated with lung cancer; differences in the association with age and gender have been suggested. We conducted a pooled analysis of individual data from 10 studies (3688...
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