Article
Genetic variants of myeloperoxidase and lung cancer risk.
Carcinogenesis - 1 Jun 2000
Schabath M B, Spitz M R, Zhang X, Delclos G L, Wu X
Abstract excerpt
The cytochrome P450 family of enzymes is responsible for many of the initial metabolic conversions of procarcinogenic compounds in tobacco smoke to reactive metabolites. However, other enzyme-based systems such as myeloperoxidase (MPO) may also be involved in this metabolic process. MPO is a phase I metabolic enzyme that has a polymorphic region upstream of the gene that appears to reduce transcriptional...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.