Article
Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis.
European journal of human genetics : EJHG - 1 Aug 2002
Lu Shemin, Nordquist Niklas, Holmberg Jens, Olofsson Peter, Pettersson Ulf, Holmdahl Rikard
Abstract excerpt
Pristane-induced arthritis (PIA) in rats is an animal model for rheumatoid arthritis (RA). We have previously identified seven quantitative trait loci (QTLs), which regulate arthritis development using a cross between the susceptible DA strain and the resistant E3 strain of rats (Pia2-8). In the present study the inbred rat strain LEW.1F was used as the susceptible strain in a cross with the E3 strain. The...
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