Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats.

doi:10.1038/3887

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Article

Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats.

Nature genetics - 1 Dec 1998

Vingsbo-Lundberg C, Nordquist N, Olofsson P, Sundvall M, Saxne T, Pettersson U, Holmdahl R

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic and genetically complex inflammatory disorder that leads to erosive destruction of peripheral joints. The use of animal models mimicking RA, such as pristane-induced arthritis (PIA) in rats, should facilitate its genetic analysis. Pristane is a non-immunogen...

Topics

Animals
Arthritis, Rheumatoid
Chromosome Mapping
Chronic Disease
Disease Models, Animal
Female
Male
Phenotype
Rats
Severity of Illness Index

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