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Article

Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats.

Nature genetics - 1 Dec 1998

Vingsbo-Lundberg C, Nordquist N, Olofsson P, Sundvall M, Saxne T, Pettersson U, Holmdahl R

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic and genetically complex inflammatory disorder that leads to erosive destruction of peripheral joints. The use of animal models mimicking RA, such as pristane-induced arthritis (PIA) in rats, should facilitate its genetic analysis. Pristane is a non-immunogenic synthetic oil that, after a single subcutaneous injection into DA rats, induces arthritis restricted to peripheral...

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Identifiers

PMID: 9843218
DOI: 10.1038/3887
PMCID: PMC7097458

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