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Article

Finemapping of the arthritis QTL Pia7 reveals co-localization with Oia2 and the APLEC locus.

Genes and immunity - 1 Apr 2010

Rintisch C, Kelkka T, Norin U, Lorentzen J C, Olofsson P, Holmdahl R

Abstract excerpt

In this study, we sought to determine the effect of the quantitative trait locus Pia7 on arthritis severity. The regulatory locus derived from the arthritis-resistant E3 rat strain was introgressed into the arthritis-susceptibility DA strain through continuous backcrossing. Congenic rats were studied for their susceptibility to experimental arthritis using pristane and adjuvant oil. In addition, cell number and...

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PMID: 20200546
DOI: 10.1038/gene.2010.2

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