Modulation of multiple experimental arthritis models by collagen‐induced arthritis quantitative trait loci isolated in congenic rat lines: Different effects of non–major histocompatibility complex quantitative trait loci in males and females

Abstract excerpt

OBJECTIVE: Collagen-induced arthritis (CIA) is a model of inflammatory arthritis with many similarities to rheumatoid arthritis (RA). We previously mapped in F(2) offspring of CIA-susceptible DA and CIA-resistant F344 rats, 5 quantitative trait loci (QTLs) for which F344 alleles were associated with reduced CIA severity. In the present study, we sought to characterize the independent arthritis-modulating effects...

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