Article
The promise and obstacle of p53 as a cancer therapeutic agent.
Current molecular medicine - 1 Jun 2002
Willis A C, Chen X
Abstract excerpt
p53 is a tumor suppressor gene that is mutated in greater than 50% of human cancers. The action of p53 as a tumor suppressor involves inhibition of cell proliferation through cell cycle arrest and/or apoptosis. Loss of p53 function therefore allows the uncontrolled proliferation associated with cancerous cells. While design of most anti-cancer agents has focused on targeting and inactivating cancer promoting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.