Article
Improving cancer therapy through p53 management.
Cell cycle (Georgetown, Tex.) - 1 Jul 2004
Haupt Susan, Haupt Ygal
Abstract excerpt
The tumor suppressor p53 normally acts to appropriately coordinate cellular responses to stress stimuli. When p53 activity is disabled, the onset of malignancy is a potential consequence. Engendering wild type p53 activities in cells that lack these functions is an approach that is currently being explored for cancer therapy. Eliciting elevated levels of active p53, imparting p53 activities through gene therapy,...
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