Article
Therapeutic exploitation of the p53 pathway.
Trends in molecular medicine - 1 Jan 2002
Lane David P, Lain Sonia
Abstract excerpt
Analysis of the gene encoding p53 could serve to evaluate the effectiveness of a cancer treatment. Mutations in this gene occur in half of all human cancers, and regulation of the protein is defective in a variety of others. Novel strategies that exploit our knowledge of the function and regulati...
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