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Article

Therapeutic exploitation of the p53 pathway.

Trends in molecular medicine - 1 Jan 2002

Lane David P, Lain Sonia

Abstract excerpt

Analysis of the gene encoding p53 could serve to evaluate the effectiveness of a cancer treatment. Mutations in this gene occur in half of all human cancers, and regulation of the protein is defective in a variety of others. Novel strategies that exploit our knowledge of the function and regulation of p53 are being actively investigated. Strategies directed at treating tumours that have p53 mutations include gene...

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Identifiers

PMID: 11927286
DOI: 10.1016/s1471-4914(02)02309-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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