Article

Targeting Therapies for the p53 Protein in Cancer Treatments

2018-07-05

Abstract excerpt

Half of all human cancers contain TP53 mutations, and in many other cancers, the function of the p53 protein is compromised. The diversity of these mutations and phenotypes presents a challenge to the development of drugs that target p53 mutant cancer cells. This review describes the rationale for many different approaches in the development of p53 targeted therapies: ( a) viruses and gene therapies, ( b) increase...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2366ac61-b9df-5a8f-94e3-cff6bfe6b66f
DOI: 10.1146/annurev-cancerbio-030518-055455

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Therapies for the p53 Protein in Cancer TreatmentsDOI 10.1146/annurev-cancerbio-030518-055455Read

Targeting mutant p53 in cancer: from mechanistic insights to therapeutic strategies.Semantic proximity Read

Side-Stepping the Guardian of the Genome: Current Cancer Therapeutics Targeting Mutant p53Semantic proximity Read

Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and OpportunitiesSemantic proximity Read

Strategies for manipulating the p53 pathway in the treatment of human cancer.Semantic proximity Read

New therapeutic strategies to treat human cancers expressing mutant p53 proteins.Semantic proximity Read

The promise and obstacle of p53 as a cancer therapeutic agent.Semantic proximity Read

Strategies for therapeutic targeting of the p53 pathway in cancer.Semantic proximity Read

Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer.Semantic proximity Read

Therapeutic exploitation of the p53 pathway.Semantic proximity Read

Improving cancer therapy through p53 management.Semantic proximity Read

Drugs Targeting p53 Mutations with FDA Approval and in Clinical TrialsSemantic proximity Read

Drugging p53 in cancer: one protein, many targets.Semantic proximity Read