Article
p53 as a therapeutic target.
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland - 1 Aug 2008
Staples O D, Steele R J C, Lain S
Abstract excerpt
Since the discovery of p53, a vast wealth of knowledge on its function and regulation has been accumulated. It is known that it is a key tumour suppressor and that its function is lost in many types of cancers, either by mutation or by excessive negative regulation. Recently, several discoveries have re-energised P53 as a therapeutic target as it has been shown that reintroduction of functional p53 into tumours...
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