Therapeutic targeting of the p53 tumor suppressor gene.

doi:10.1016/s0958-1669(96)80069-3

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Article

Therapeutic targeting of the p53 tumor suppressor gene.

Current opinion in biotechnology - 1 Dec 1996

Beaudry G A, Bertelsen A H, Sherman M I

Abstract excerpt

The p53 tumor suppressor gene is a logical target for cancer therapy. Several therapeutic strategies can be envisioned based upon recent advances concerning structure and function of the p53 protein, its interaction with cellular and viral proteins and its roles in repairing DNA, regulating cell...

Topics

Antineoplastic Agents
Gene Expression Regulation, Neoplastic
Genes, p53
Genetic Therapy
Genetic Vectors
Humans
Mutation
Neoplasms
Tumor Suppressor Protein p53

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