p53 as a therapeutic target: unresolved issues on the road to cancer therapy targeting mutant p53.

Abstract excerpt

As a tumor suppressor, p53 has a central role in oncogenesis: it inhibits the growth of abnormal cells and thus prevents cancer development. The frequent occurrence of p53 mutations in human cancer and its role as "guardian of the genome" has led to numerous investigations evaluating its role as a potential therapeutic target in terms of restoring wild type (wt) p53 and thereby either reverting the malignant...

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• Apoptosis
• Drug Delivery Systems
• Genes, p53
• Mutation
• Neoplasms