Article
Biased Iglambda expression in hypermutated IgD multiple myelomas does not result from receptor revision.
Leukemia - 1 Jul 2002
van der Burg M, Bende R J, Aarts W M, Langerak A W, van Dongen J J M, van Noesel C J M
Abstract excerpt
Normal IgM(-)IgD(+) CD38(+) B cells and IgM(-)IgD(+) multiple myelomas (MM) are characterized by Cmu deletion, biased Iglambda expression and hypermutated IgV regions. The predominant Iglambda usage has been proposed as resulting from secondary Ig gene rearrangements during extensive clonal expansion in the germinal center environment. Here, four cases of IgDlambda MM were studied to address the question of light...
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