Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors.

Journal of the American Society of Nephrology : JASN - 1 Jul 2002

Siegsmund Michael, Brinkmann Ulrich, Scháffeler Elke, Weirich Gregor, Schwab Matthias, Eichelbaum Michel, Fritz Peter, Burk Oliver, Decker Jochen, Alken Peter, Rothenpieler Uwe, Kerb Reinhold, Hoffmeyer Sven, Brauch Hiltrud

Abstract excerpt

Except for hereditary disease, genetic factors that contribute to the development of renal epithelial tumors are unknown. There is a possibility that the MDR1 encoded plasma membrane transporter P-glycoprotein (PGP) influences the risk of development of renal neoplasms. PGP is known to be involved in uptake, binding, transport, and distribution of xenobiotics. There is evidence that the MDR1(C3435T) polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Genes, MDR

Share to Kidney

Share to Kidney Neoplasms

Share to Reference Values

Share to White People

Source

Identifiers

PMID: 12089380
DOI: 10.1097/01.asn.0000019412.87412.bc

Genes

PGP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors.PMID 12089380Read ↗

MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case-control studies.Semantic proximity Read ↗

MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies.Semantic proximity Read ↗

Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes.Semantic proximity Read ↗

Possible roles of the xenobiotic transporter P-glycoproteins encoded by the MDR1 3435 C>T gene polymorphism in differentiated thyroid cancers.Semantic proximity Read ↗

Impact of glutathione transferase M1, T1, and P1 gene polymorphisms in the genetic susceptibility of North Indian population to renal cell carcinoma.Semantic proximity Read ↗

Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma.Semantic proximity Read ↗

MDR1 C3435T polymorphism in patients with breast cancer.Semantic proximity Read ↗

GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer.Semantic proximity Read ↗

Glutathione S-transferase M1, T1, and P1 polymorphisms as risk factors for renal cell carcinoma: a case-control study.Semantic proximity Read ↗

Effect of MDR1 gene polymorphism on progression of end-stage renal disease.Semantic proximity Read ↗

Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer.Semantic proximity Read ↗

Chromosome 11q13.3 variant modifies renal cell cancer risk in a Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.