MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case-control studies.

Abstract excerpt

BACKGROUND: P-glycoprotein, the product of the MDR1 gene, is a transmembrane active efflux pump for a variety of environmental toxins and xenobiotics. Epidemiological studies have evaluated the association between MDR1 C3435T polymorphism and cancer susceptibility. However, published data are still inconclusive. METHODS: To derive a more precise assessment of this relevance, we performed a meta-analysis, up to...

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• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Case-Control Studies
• Cohort Studies
• Gene Frequency