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Article

MDR1 C3435T polymorphism in patients with breast cancer.

Archives of medical research - 1 Jul 2007

Turgut Sebahat, Yaren Arzu, Kursunluoglu Raziye, Turgut Günfer

Abstract excerpt

BACKGROUND: The human multidrug-resistant gene (MDR1) encodes P-glycoprotein (Pgp), a membrane-bound efflux transporter conferring resistance to a number of natural cytotoxic drugs and potentially toxic xenobiotics. Single-nucleotide polymorphisms (SNPs) in MDR1 gene are associated with phenotypic variation in Pgp expression levels of tissue. SNPs may alter the physiological protective role of Pgp and, therefore,...

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Lymphatic Metastasis
Age of Onset
ATP Binding Cassette Transporter, Subfamily B, Member 1
Breast Neoplasms
Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

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PMID: 17560460
DOI: 10.1016/j.arcmed.2007.02.005

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