MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies.

doi:10.1007/s11033-012-1554-7

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Article

MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies.

Molecular biology reports - 1 Jul 2012

Sheng Xiaojing, Zhang Limei, Tong Na, Luo Dewei, Wang Meilin, Xu Min, Zhang Zhengdong

Abstract excerpt

Multidrug resistance 1 (MDR1) gene encodes the ATP-dependent cellular efflux pump P-glycoprotein (P-gp) which efflux of a variety of substances across the membrane. P-gp could serve a role in cancer etiology based on its physiological role of protecting cells from xenobiotics or metabolites. The C3435T (rs1045642) polymorphism of the MDR1 gene which could influence the P-gp expression and function have been...

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PMID: 22311042
DOI: 10.1007/s11033-012-1554-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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