Article
Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma.
Annals of hepatology - 1 Jan 2000
Baldissera Vanessa Dido, de Mattos Angelo Alves, Coral Gabriela Perdomo, de Araujo Fernanda Branco, Marroni Cláudio Augusto, de Mello Brandão Ajácio Bandeira, Ott Fontes Paulo Roberto, Schmidt Cerski Carlos Thadeu, Hartmann Antonio Atalibio, Kretzmann Filho Nélson Alexandre
Abstract excerpt
INTRODUCTION: Considering the high prevalence of liver tumors and the impact on patient survival, a greater understanding of the biological behavior of those tumors if of great importance. The multidrug resistance gene (MDR1) may present as single nucleotide polymorphism (SNP) which can affect the expression and activity of P-glycoprotein (Pgp), and high expression of Pgp has been associated with a worse...
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