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Mechanism of Increased Fluconazole Resistance in <i>Candida glabrata</i> during Prophylaxis

22 Apr 2004

Abstract excerpt

Candida glabrata can become resistant to fluconazole, causing persistent colonization and invasive infection during prolonged exposure to the drug. To determine the mechanism of resistance in this setting, weekly oropharyngeal cultures for C. glabrata were obtained over a 2-year period from hematopoietic stem cell transplant recipients who were receiving fluconazole prophylaxis. In 20 patients from whom at least...

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PMID: 15105134
DOI: 10.1128/aac.48.5.1773-1777.2004

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