Article
Genetic polymorphisms of glutathione S-transferase A1, the major glutathione S-transferase in human liver: consequences for enzyme expression and busulfan conjugation.
Clinical pharmacology and therapeutics - 1 Jun 2002
Bredschneider Monika, Klein Kathrin, Mürdter Thomas E, Marx Claudia, Eichelbaum Michel, Nüssler Andreas K, Neuhaus Peter, Zanger Ulrich M, Schwab Matthias
Abstract excerpt
BACKGROUND: High-dose busulfan is widely used as part of conditioning regimens for patients who are undergoing hematopoietic stem cell or bone marrow transplantation. High plasma concentrations of busulfan have been linked to the occurrence of hepatic venoocclusive disease (VOD), a severe complication associated with a high mortality. Because conjugation with glutathione, the major route of biotransformation of...
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