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Genetic polymorphism in metabolism and host defense enzymes: Implications for human health risk assessment

21 Jul 2010

Abstract excerpt

Genetic polymorphisms in xenobiotic metabolizing enzymes can have profound influence on enzyme function, with implications for chemical clearance and internal dose. The effects of polymorphisms have been evaluated for certain therapeutic drugs but there has been relatively little investigation with environmental toxicants. Polymorphisms can also affect the function of host defense mechanisms and thus modify the...

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PMID: 20662711
DOI: 10.3109/10408441003742895

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