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Article

Glutathione Transferase Gene Variants Influence Busulfan Pharmacokinetics and Outcome After Myeloablative Conditioning.

Therapeutic drug monitoring - 1 Aug 2015

Bremer Sara, Fløisand Yngvar, Brinch Lorentz, Gedde-Dahl Tobias, Bergan Stein

Abstract excerpt

BACKGROUND: Busulfan (Bu) and cyclophosphamide (Cy) are frequently included in conditioning regimens before hematopoietic stem cell transplantation (HSCT). Both drugs are detoxified by glutathione transferases (GST), and GST gene variants may explain some of the interindividual variability in pharmacokinetics and drug toxicity. METHODS: The study investigated adult patients (n = 114) receiving oral Bu pre-HSCT....

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Identifiers

PMID: 25565670
DOI: 10.1097/FTD.0000000000000180
PMCID: PMC4505914

Genes

GSTM1
GSTA1

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