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Article

Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation.

Blood - 1 Sept 2004

Srivastava Alok, Poonkuzhali Balasubramanian, Shaji Ramachandran V, George Biju, Mathews Vikram, Chandy Mammen, Krishnamoorthy Rajagopal

Abstract excerpt

Hepatic venoocclusive disease (HVOD) in bone marrow transplantation (BMT) is attributed to toxicity of cytoreductive agents, especially busulfan and cyclophosphamide, in the conditioning therapy. Busulfan, as well as the metabolites of cyclophosphamide, are conjugated with glutathione (GSH), catalyzed by enzymes of the glutathione S-transferase (GST) family. To assess the impact of polymorphisms of the GST genes,...

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Source

Identifiers

PMID: 15142875
DOI: 10.1182/blood-2003-11-3778

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation.PMID 15142875Read ↗

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Glutathione S-Transferase M1 polymorphism – A risk factor for hepatic venoocclusive disease in bone marrow transplantationSemantic proximity Read ↗

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A deletion polymorphism in glutathione-S-transferase mu (GSTM1) and/or theta (GSTT1) is associated with an increased risk of toxicity after autologous blood and marrow transplantation.Semantic proximity Read ↗

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