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Article

Exploratory analysis of 1936 SNPs in ADME genes for association with busulfan clearance in adult hematopoietic stem cell recipients.

Pharmacogenetics and genomics - 1 Dec 2013

Ten Brink Marloes H, Swen Jesse J, Böhringer Stefan, Wessels Judith A M, van der Straaten Tahar, Marijt Erik W A, von dem Borne Peter A, Zwaveling Juliëtte, Guchelaar Henk-Jan

Abstract excerpt

BACKGROUND: Busulfan is used in preparative regimens before stem cell transplantation. There is significant interpatient variability in busulfan pharmacokinetics (PK) and exposure is related to outcome. Polymorphisms in genes encoding glutathione-S-transferases have been associated with busulfan PK but only explain a limited portion of the observed variability. AIM: The aim of this study is to identify additional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24192531
DOI: 10.1097/FPC.0000000000000007

Genes

GSTA5

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