Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gilbert syndrome redefined: a complex genetic haplotype influences the regulation of glucuronidation.

Hepatology (Baltimore, Md.) - 1 Jun 2012

Ehmer Ursula, Kalthoff Sandra, Fakundiny Bastian, Pabst Brigitte, Freiberg Nicole, Naumann Ronald, Manns Michael P, Strassburg Christian P

Abstract excerpt

UNLABELLED: Gilbert syndrome (GS) is characterized by intermittent unconjugated hyperbilirubinemia without structural liver damage, affecting about 10% of the white population. In GS the UGT1A1*28 variant reduces bilirubin conjugation by 70% and is associated with irinotecan and protease inhibitor side effects. The aim of this study was to characterize potential in vivo consequences of UGT1A gene variability in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Donors
Share to Gilbert Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronides

Share to Glucuronosyltransferase

Share to Lipopolysaccharides

Share to Multidrug Resistance-Associated Protein 2

Share to Polychlorinated Dibenzodioxins

Share to Transcriptional Activation

Source

Identifiers

PMID: 22213127
DOI: 10.1002/hep.25561

Genes

ABCC2
HBD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gilbert syndrome redefined: a complex genetic haplotype influences the regulation of glucuronidation.PMID 22213127Read ↗

Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability.Semantic proximity Read ↗

Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?Semantic proximity Read ↗

Pharmacogenetics of Gilbert's syndrome.Semantic proximity Read ↗

Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance.Semantic proximity Read ↗

UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females.Semantic proximity Read ↗

UGT genomic diversity: beyond gene duplication.Semantic proximity Read ↗

Integrated analysis of UGT1A1 promoter polymorphism, gene expression, and IL-1β reveals genotype-driven susceptibility in Gilbert syndrome.Semantic proximity Read ↗

Gilbert Syndrome: The <i>UGT1A1</i> *28 Promoter Polymorphism as a Biomarker of Multifactorial Diseases and Drug MetabolismSemantic proximity Read ↗

The Impact of UGT1A1 Genetic Variability on Enzyme Expression in Liver Pathology.Semantic proximity Read ↗

Genetic variants of UDP-glucuronosyltransferase 1A genes are associated with disease presentation and outcome in primary sclerosing cholangitis.Semantic proximity Read ↗

Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.Semantic proximity Read ↗

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.