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Article

Structural elucidation of a PRP8 core domain from the heart of the spliceosome.

Nature structural & molecular biology - 1 Nov 2008

Ritchie Dustin B, Schellenberg Matthew J, Gesner Emily M, Raithatha Sheetal A, Stuart David T, Macmillan Andrew M

Abstract excerpt

The spliceosome is a complex ribonucleoprotein (RNP) particle containing five RNAs and more than 100 associated proteins. One of these proteins, PRP8, has been shown to interact directly with the splice sites and branch region of precursor-mRNAs (pre-mRNAs) and spliceosomal RNAs associated with catalysis of the two steps of splicing. The 1.85-A X-ray structure of the core of PRP8 domain IV, implicated in key...

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PMID: 18836455
DOI: 10.1038/nsmb.1505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Structural elucidation of a PRP8 core domain from the heart of the spliceosome.PMID 18836455Read ↗

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