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Article

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.

Genes & development - 1 Aug 1999

Siatecka M, Reyes J L, Konarska M M

Abstract excerpt

A U5 snRNP protein, hPrp8, interacts closely with the GU dinucleotide at the 5' splice site (5'SS), forming a specific UV-inducible cross-link. To test if this physical contact between the 5'SS and the carboxy-terminal region of Prp8 reflects a functional recognition of the 5'SS during spliceosome assembly, we mutagenized the corresponding region of yeast Prp8 and screened the resulting mutants for suppression of...

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Identifiers

PMID: 10444596
DOI: 10.1101/gad.13.15.1983
PMCID: PMC316927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.PMID 10444596Read ↗

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