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Article

The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.

Diabetes - 1 Jul 2002

Marion Evelyne, Kaisaki Pamela Jane, Pouillon Valérie, Gueydan Cyril, Levy Jonathan C, Bodson André, Krzentowski Georges, Daubresse Jean-Claude, Mockel Jean, Behrends Jens, Servais Geneviève, Szpirer Claude, Kruys Véronique, Gauguier Dominique, Schurmans Stéphane

Abstract excerpt

Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene. Here we report the presence of SHIP2 gene mutations associated with type 2 diabetes in rats and humans. The R1142C mutation specifically identified in Goto-Kakizaki (GK) and...

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Identifiers

PMID: 12086927
DOI: 10.2337/diabetes.51.7.2012

Genes

INPPL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.PMID 12086927Read ↗

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