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Article

Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.

Diabetes - 1 Jul 2004

Kaisaki Pamela J, Delépine Marc, Woon Peng Y, Sebag-Montefiore Liam, Wilder Steven P, Menzel Stephan, Vionnet Nathalie, Marion Evelyne, Riveline Jean-Pierre, Charpentier Guillaume, Schurmans Stéphane, Levy Jonathan C, Lathrop Mark, Farrall Martin, Gauguier Dominique

Abstract excerpt

Type II SH2 domain-containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity. INPPL1 mutations affecting gene function have been found in rat models of type 2 diabetes and hypertension and in type 2 diabetic patients. We investigated the influence of nucleotide variation in INPPL1 on components of the metabolic syndrome. Following comprehensive resequencing...

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Source

Identifiers

PMID: 15220217
DOI: 10.2337/diabetes.53.7.1900

Genes

INPPL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.PMID 15220217Read ↗

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