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Article

Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome.

American journal of physiology. Endocrinology and metabolism - 1 Jun 2007

Buettner Roland, Ottinger Iris, Gerhardt-Salbert Christiane, Wrede Christian E, Schölmerich Jürgen, Bollheimer L Cornelius

Abstract excerpt

The lipid phosphatase SH2 domain-containing lipid phosphatase (SHIP2) has been implicated in the regulation of insulin sensitivity, but its role in the therapy of insulin-resistant states remains to be defined. Here, we examined the effects of an antisense oligonucleotide (AS) therapy directed against SHIP2 on whole body insulin sensitivity and insulin action in liver and muscle tissue in a dietary rodent model...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oligonucleotides, Antisense

Share to Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

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Source

Identifiers

PMID: 17327370
DOI: 10.1152/ajpendo.00263.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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