Article
A form of the metabolic syndrome associated with mutations in DYRK1B.
The New England journal of medicine - 15 May 2014
Keramati Ali R, Fathzadeh Mohsen, Go Gwang-Woong, Singh Rajvir, Choi Murim, Faramarzi Saeed, Mane Shrikant, Kasaei Mohammad, Sarajzadeh-Fard Kazem, Hwa John, Kidd Kenneth K, Babaee Bigi Mohammad A, Malekzadeh Reza, Hosseinian Adallat, Babaei Masoud, Lifton Richard P, Mani Arya
Abstract excerpt
BACKGROUND: Genetic analysis has been successful in identifying causative mutations for individual cardiovascular risk factors. Success has been more limited in mapping susceptibility genes for clusters of cardiovascular risk traits, such as those in the metabolic syndrome. METHODS: We identified three large families with coinheritance of early-onset coronary artery disease, central obesity, hypertension, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.