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Article

SHIP2: a "new" insulin pathway target for aging research.

Rejuvenation research - 1 Apr 2014

Accardi Giulia, Virruso Claudia, Balistreri Carmela Rita, Emanuele Fabrizio, Licastro Federico, Monastero Roberto, Porcellini Elisa, Vasto Sonya, Verga Salvatore, Caruso Calogero, Candore Giuseppina

Abstract excerpt

Strong evidence suggests that systemic inflammation and central adiposity contribute to and perpetuate metabolic syndrome. All of these alterations predispose individuals to type 2 diabetes mellitus (T2DM), cardiovascular disease, as well as Alzheimer's disease (AD), all characterized by chronic inflammatory status. On the other hand, extensive abnormalities in insulin and insulin-like growth factor I (IGF-I) and...

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PMID: 24313349
DOI: 10.1089/rej.2013.1541

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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