Article
Association of SH-2 containing inositol 5'-phosphatase 2 gene polymorphisms and hyperglycemia.
Pancreas - 1 Jul 2006
Ishida Satoru, Funakoshi Akihiro, Miyasaka Kyoko, Shimokata Hiroshi, Ando Fujiko, Takiguchi Soichi
Abstract excerpt
OBJECTIVES: SH-2 containing inositol 5'-phosphatase 2 (SHIP2) is a family of inositol 5'-phosphatases, which possess the 5'-phosphatase activity that hydrolyzes phosphatidylinositol-3, 4, 5-trisphosphate to phosphatidylinositol-3, 4-bisphosphate and is suspected to negatively regulates the metabolic signaling of insulin. To clarify the possible involvement of SHIP2 in physiological abnormalities, we examined the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
