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Article

Comparative Genome of GK and Wistar Rats Reveals Genetic Basis of Type 2 Diabetes.

PloS one - 1 Jan 2015

Liu Tiancheng, Li Hong, Ding Guohui, Wang Zhen, Chen Yunqin, Liu Lei, Li Yuanyuan, Li Yixue

Abstract excerpt

The Goto-Kakizaki (GK) rat, which has been developed by repeated inbreeding of glucose-intolerant Wistar rats, is the most widely studied rat model for Type 2 diabetes (T2D). However, the detailed genetic background of T2D phenotype in GK rats is still largely unknown. We report a survey of T2D susceptible variations based on high-quality whole genome sequencing of GK and Wistar rats, which have generated a list...

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Diabetes Mellitus, Type 2
Genetic Loci
Genome
Polymorphism, Genetic
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26529237
DOI: 10.1371/journal.pone.0141859
PMCID: PMC4631338

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