Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.

doi:10.1038/sj.ejhg.5200806

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Article

Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.

European journal of human genetics : EJHG - 1 May 2002

Bonafè Massimiliano, Marchegiani Francesca, Cardelli Maurizio, Olivieri Fabiola, Cavallone Luca, Giovagnetti Simona, Pieri Carlo, Marra Maurizio, Antonicelli Roberto, Troiano Leonarda, Gueresi Paola, Passeri Giovanni, Berardelli Maurizio, Paolisso Giuseppe, Barbieri Michelangela, Tesei Silvia, Lisa Rosmarie, De Benedictis Giovanna, Franceschi Claudio

Abstract excerpt

Human Paraoxonase (PON1) is a High-Density Lipoprotein (HDL)-associated esterase that hydrolyses lipo-peroxides. PON1 has recently attracted attention as a protective factor against oxidative modification of LDL and may therefore play an important role in the prevention of the atherosclerotic process. Two polymorphisms have been extensively studied: a Leucine (L allele) to Methionine (M allele) substitution at...

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PMID: 12082503
DOI: 10.1038/sj.ejhg.5200806

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PON1

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Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.PMID 12082503Read ↗

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The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux.Semantic proximity Read ↗

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